Protein Details: Potassium channel subfamily K member 2
Protein ID
ICDB_Pro_0717
Protein Name
Potassium channel subfamily K member 2
Gene Name
Kcnk2
Organism
Mus musculus (Mouse)
Length
426 amino acids
AlphaFoldDB
AF-P97438-F1-model_v4.pdb
Function
Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes; forms mostly heterodimeric potassium channels with KCNK1; with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes; the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors; such as F2R and CNR1.
Sequence
Ligand Binding
Binding Site
Disease
Location
Detected in hippocampus astrocytes (at protein level) (PubMed:24496152). High expression in brain and lung. Also detected in kidney; heart and skeletal muscle. Also detected in kidney; heart and skeletal muscle. Also detected in kidney; heart and skeletal muscle. Not detected in liver. In the brain; highest expression in olfactory bulb; hippocampus and cerebellum.
DOI ID
10.1002/j.1460-2075.1996.tb01077.x; 10.1073/pnas.0600463103; 10.1371/journal.pbio.1000112; 10.1038/8084; 10.1016/j.cell.2010.12.001; 10.1172/jci59410; 10.1038/ncomms4227; 10.1172/jci79562
RefSeq
NP_001153322.1 [P97438-1]; NP_034737.2 [P97438-2]